Thanks for starting a fun topic!
I think my favorite Street ride is Crossing town on 120th street from St. Nic's to the Water. On the East side looking South the avenues look like canyons in midtown and beyond. You hit the water where the East Channel is wide and it looks different every day depending on the weather and tide. It can be glassy or crazy. The sky is about as big as it gets from Manhattan.
I love riding any of the bridges in the city (except the Broadway bridge to Marble Hill 😬). The Henry Hudson and the Queensboro are probably my favorite bridges to ride on.